急性脑梗死患者VEGF浓度变化与NIHSS评分的关系

　　[摘要] 目的 探讨急性脑梗死患者血管内皮生长因子（VEGF）浓度变化与美国国立卫生研究院卒中量表（NIHSS）评分的关系。 方法 选择2014年6月～2015年6月期间我院神经内科诊断为急性脑梗死的初诊的住院患者30例为脑梗死组，45例健康体检者为对照组，均抽空腹肘静脉血2 mL。脑梗死组患者入院当天、第3、7、14、28天各抽血1次；对照组健康者抽血1次，取血清，采用双抗体夹心ELISA法检测VEGF，并对患者各时间点进行NIHSS评分。结果 脑梗死组患者发病第1、3、7、14、28天血VEGF浓度分别为（203.76±47.36）ng/L、（207.35±49.83）ng/L、（214.53±55.87）ng/L、（203.78±42.39）ng/L、（188.34±42.82）ng/L，均高于对照组的（185.97±53.36）ng/L，第7天血VEGF浓度显著增高（t=2.421，P<0.05），其他时间点差异无统计学意义（P>0.05）。相应时间点的NIHSS 评分脑梗死组比较差异有统计学意义（F=5.176，P=0012），随着时间的延长，NIHSS评分逐渐降低；急性脑梗死组患者发病第1、3、7、14、28天血VEGF浓度与NIHSS评分呈负相关。 结果 血清VEGF的浓度变化结合NIHSS评分可作为急性脑梗死组患者诊断和预后疗效的评价指标，对临床具有一定的指导意义。
　　[关键词] 急性脑梗死；VEGF；NIHSS；预后
　　[Abstract] Objective To investigate the reiationship between serum vascular endothelial growth factor （VEGF） and the United States national institutes of health stroke scale（NIHSS） scores. Methods From June 2014 to June 2015 in our hospital， 30 patients with acute ischemic stroke were included in our study as ischemic stroke group， with 45 healthy adults as control group. All patients were abdominal venous blood 2 mL. The ischemic stroke group admitted to hospital on the 0 day， 3， 7， 14， 28 days abdominal venous blood each 1 time； The control group abdominal venous blood 1 time， the VEGF was detected by double antibody sandwich ELISA method， and NIHSS scores with each point in time between the two groups were observed. Results The hematic VEGF concentration onset of cerebral infarction patients at 1， 3， 7， 14， 28 days were（203.76±47.36） ng/L， （207.35±49.83） ng/L， （214.53±55.87） ng/L， （203.78±42.39） ng/L， （188.34±42.82） ng/L respectively， were higher than the control group （185.97±53.36） ng/L， hematic VEGF concentration was significantly increased at 7 days（t=2.421， P<0.05）， there was no statistically significant difference between the two other time points（P>0.05）. The difference of corresponding time point of NIHSS score comparison of cerebral infarction group was statistically significant（F=5.176， P=0012）， with the extension of time， the NIHSS score gradually reduced； The hematic VEGF concentration onset of acute cerebral infarction patients at 1， 3， 7， 14， 28 days were negative correlated to NIHSS scores. Conclusion The level of VEGF combined with NIHSS can be served as a diagnostic and prognosis marker of acute ischemic stroke.
　　[Key words] Acute ischemic stroke； Vascular endothelial growth factor（VEGF）； National institutes of health stroke scale （NIHSS）； Prognosis